![]() ![]() ![]() For every 1 cc/kg of platelet transfused, odds of next-day delirium increased by 9% (odds ratio 1.09, 95% CI 1.03–1.51). MSM demonstrated a 75% increase in the development of next-day delirium after transfusion of platelets (aOR 1.75, 95% CI 1.03–2.97). To account for time-dependent confounding, a marginal structural model (MSM) was constructed to delineate the relationship between platelet transfusion and next-day delirium. Data obtained included severity of illness, level of respiratory support, exposure to medications and blood products, as well as daily cognitive status. We performed a single-center retrospective cohort analysis including children admitted to the PICU between 20 who were transfused platelets within the first 14 days of admission. ![]() We hypothesized that receipt of platelets would be associated with delirium development in a pediatric intensive care unit (PICU). Platelet transfusions may potentiate the body’s pro-inflammatory responses. ![]() Inflammation has been implicated as a mechanism for the development of delirium. Delirium is a frequent, serious, and preventable complication in critically ill children. ![]()
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